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Animal models
Items for "Animal models"
Anti-metastatic effects of serine protease inhibitors: animal models for analysis
To date, no effective adjuvant drug preventing the aggressive spread of tumour cells in late stages of cancer disease or at the time-point of primary tumour removal is available...
Keywords: Tiermodelle, Serinproteasen, Proteaseinhibitoren, Metastasierung, Screening, Lymphom, Fibrosarkom
01/2007 | Hämostaseologie, SchattauerNeutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization
Early deep venous thrombosis (DVT) resolution is associated with neutrophil (PMN) influx. This study examined the role of PMNs in thrombus neovascularization and vein wall injury after DVT...
Keywords: Animal models, tissue remodelling, leukocyte function / activation, deep vein thrombosis
00/0000 | Thrombosis and Haemostasis, SchattauerResolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation
P-selectin inhibition has been shown to decrease thrombogenesis in multiple animal species. In this study, we show that a novel oral small-molecule inhibitor of P-selectin, PSI-697, promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis...
Keywords: Deep venous thrombosis, thrombus resolution, small-molecule inhibitor of p-selectin, inflammation, Animal models
03/2007 | Thrombosis and Haemostasis, Schattauer