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Items for "Angiogenesis and inhibitors"

Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin v3 induces signal transduction and enhances plasminogen activation

It has been questioned whether there are receptors for urokinase-type plasminogen activator (uPA) that facilitate plasminogen activation other than the high affinity uPA receptor (uPAR/CD87) since studies of uPAR knockout mice did not support a major role of uPAR in plasminogen activation...

Keywords: Adhesion receptors / integrins, adhesion molecules, cell migration, Angiogenesis and inhibitors, plasminogen activators

03/2006 | Thrombosis and Haemostasis, Schattauer
Thrombin activation of endometrial endothelial cells: A possible role in intrauterine growth restriction

Preeclampsia (PE), intrauterine growth restriction (IUGR) and abruption with or without fetal loss are associated with reduced uteroplacental blood flow, decidual vasculopathy, endothelial cell dysfunction, thrombosis, inflammation and hemorrhage...

Keywords: Angiogenesis and inhibitors, pregnancy, inflammation, haemostasis, cytokines

00/0000 | Thrombosis and Haemostasis, Schattauer
uPAR uPA PAI-1 interactions and signaling: A vascular biologists view

The urokinase-type plasminogen activator (uPA), its inhibitor PAI-1 and its cellular receptor (uPAR), play a pivotal role in pericellular proteolysis...

Keywords: Urokinase / receptor, plasminogen activator inhibitors, Angiogenesis and inhibitors, atherosclerosis, restenosis

03/2007 | Thrombosis and Haemostasis, Schattauer