Items for "amphipathic helix"

Adaptation of the behaviour of an aspartic proteinase inhibitor by relocation of a lysine residue by one helical turn

In addition to self-inhibition of aspartic proteinase zymogens by their intrinsic proparts, the activity of certain members of this enzyme family can be modulated through active-site occupation by extrinsic polypeptides such as the small IA₃ protein from Saccharomyces cerevisiae...

Keywords: amphipathic helix, extrinsic/intrinsic inhibitors of aspartic proteinases, gastric zymogen proparts, lysine superposition, pH dependence of interaction, yeast IA3 inhibitor