Membrane-bound peptidases play a key role in the control of growth, differentiation, and signal transduction of many cellular systems by degrading bioactive peptides...
Keywords: aminopeptidase, angiotensin II, bioactive peptide, Cancer, endothelin-1, oxytocin
08/2004 | Biological Chemistry, Walter de GruyterFree propeptides are known to function as inhibitors of the parental mature cysteine cathepsins...
Keywords: aminopeptidase, cysteine peptidase, inhibition, maturation, mini-chain
09/2005 | Biological Chemistry, Walter de GruyterThe N-terminus of any protein may be used as a destabilization signal for targeted protein degradation...
Keywords: aminopeptidase, co-translational, deformylase, leucine, Methionine, proteasome, protein, ubiquitin
07/2006 | Biological Chemistry, Walter de GruyterDipeptidyl peptidase III (DPP III) is a zinc exopeptidase with an implied role in the mammalian pain-modulatory system owing to its high affinity for enkephalins and localisation in the superficial laminae of the spinal cord dorsal horn...
Keywords: aminopeptidase, capillary electrophoresis, hydrolase, opioid peptides
03/2007 | Biological Chemistry, Walter de GruyterPeptide inhibitors of insulin-regulated aminopeptidase (IRAP) accelerate spatial learning and facilitate memory retention and retrieval by binding competitively to the catalytic site of the enzyme and inhibiting its catalytic activity...
Keywords: aminopeptidase, angiotensin IV, AT4 receptor, IRAP, memory
04/2007 | Biological Chemistry, Walter de Gruyter