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Items for "aminopeptidase"

Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies

Membrane-bound peptidases play a key role in the control of growth, differentiation, and signal transduction of many cellular systems by degrading bioactive peptides...

Keywords: aminopeptidase, angiotensin II, bioactive peptide, Cancer, endothelin-1, oxytocin

08/2004 | Biological Chemistry, Walter de Gruyter
Activation processing of cathepsin H impairs recognition by its propeptide

Free propeptides are known to function as inhibitors of the parental mature cysteine cathepsins...

Keywords: aminopeptidase, cysteine peptidase, inhibition, maturation, mini-chain

09/2005 | Biological Chemistry, Walter de Gruyter
Impact of the N-terminal amino acid on targeted protein degradation

The N-terminus of any protein may be used as a destabilization signal for targeted protein degradation...

Keywords: aminopeptidase, co-translational, deformylase, leucine, Methionine, proteasome, protein, ubiquitin

07/2006 | Biological Chemistry, Walter de Gruyter
Human dipeptidyl peptidase III acts as a post-proline-cleaving enzyme on endomorphins

Dipeptidyl peptidase III (DPP III) is a zinc exopeptidase with an implied role in the mammalian pain-modulatory system owing to its high affinity for enkephalins and localisation in the superficial laminae of the spinal cord dorsal horn...

Keywords: aminopeptidase, capillary electrophoresis, hydrolase, opioid peptides

03/2007 | Biological Chemistry, Walter de Gruyter
Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain

Peptide inhibitors of insulin-regulated aminopeptidase (IRAP) accelerate spatial learning and facilitate memory retention and retrieval by binding competitively to the catalytic site of the enzyme and inhibiting its catalytic activity...

Keywords: aminopeptidase, angiotensin IV, AT4 receptor, IRAP, memory

04/2007 | Biological Chemistry, Walter de Gruyter