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Items for "ADAMTS13"

Relation between ADAMTS13 activity and ADAMTS13 antigen levels in healthy donors and patients with thrombotic microangiopathies (TMA)

We have established a new, enzyme-linked immunosorbent assay (ELISA) for the detection of ADAMTS13 antigen using purified polyclonal rabbit anti-human ADAMTS13 IgG...

Keywords: ADAMTS13, ADAMTS13-antigen, ELISA, TTP, HUS

00/0000 | Thrombosis and Haemostasis, Schattauer

ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpura

Functional assays are commonly used to measure the antibodies of ADAMTS13 found in patients of thrombotic thrombocytopenic purpura (TTP)...

Keywords: ADAMTS13, thrombotic thrombocytopenic purpura, antibody

05/2006 | Thrombosis and Haemostasis, Schattauer

A common origin of the 4143insA ADAMTS13 mutation

Severely deficient activity of the von Willebrand Factor (VWF) cleaving metalloprotease, ADAMTS13, is associated with thrombotic thrombocytopenic purpura (TTP)...

Keywords: ADAMTS13, TTP, VWF, mutation

07/2006 | Thrombosis and Haemostasis, Schattauer

In-vitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura (TTP) is a disease characterized by microvascular thrombosis, often associated with deficiency of the vonWillebrand factor (VWF) cleaving protease ADAMTS13...

Keywords: thrombotic thrombocytopenic purpura, ADAMTS13, mutations, expression studies

10/2006 | Thrombosis and Haemostasis, Schattauer

Differential effects of the loss of intrachain- versus interchain-disulfide bonds in the cystine-knot domain of von Willebrand factor on the clinical phenotype of von Willebrand disease

Von Willebrand factor (VWF) contains a large number of cysteine residues, which all form disulfide bonds...

Keywords: ADAMTS13, cysteine, dimerization, disulfide bond, multimerization

12/2006 | Thrombosis and Haemostasis, Schattauer