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Items for "active site"

Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors

Proteases that digest the blood-meal of the parasitic fluke Schistosoma are potential targets for therapy of schistosomiasis, a disease of chronic morbidity in humans...

Keywords: active site, aspartyl protease, Candida, drug design, parasite

04/2005 | Biological Chemistry, Walter de Gruyter
The peptidases from fungi and viruses

Fungi and viruses encode a variety of peptidases having a plethora of functions. Many fungal peptidases are extracellular and are likely used to degrade proteins in their environment...

Keywords: active site, catalytic mechanism, catalytic triad, G1 peptidase, hepatitis A virus 3C peptidase, scytalidoglutamic peptidase

08/2006 | Biological Chemistry, Walter de Gruyter
The spliceosome: a ribozyme at heart?

The spliceosome, the multi-megadalton molecular machine that performs splicing, consists of over 200 different proteins and five small nuclear RNAs (snRNAs)...

Keywords: active site, catalysis, ribozyme, splicing mechanism, U6 snRNA

07/2007 | Biological Chemistry, Walter de Gruyter