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Items for "A549 cells"

Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA

Human A549 lung epithelial cells were challenged with 18O-labeled hydrogen peroxide ([18O]-H2O2), the total RNA and DNA extracted in parallel, and analyzed for 18O-labeled 8-oxo-7,8-dihydroguanosine ([18O]-8-oxoGuo) and 8-oxo-7,8-dihydro-2?-deoxyguanosine ([18O]-8-oxodGuo) respectively, using high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-MS/MS)...

Keywords: A549 cells, electrospray ionization, Mass spectrometry, oxidative stress, 8-oxodGuo, 8-oxoGuo

04/2005 | Biological Chemistry, Walter de Gruyter
Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells

Resveratrol is a polyphenolic chemopreventive agent that has been shown to influence cellular redox reactions...

Keywords: A549 cells, antioxidant capacity, cell cycle arrest, chemoprevention, glutathione peroxidase, selenoprotein

02/2007 | Biological Chemistry, Walter de Gruyter
Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents

In this article we studied the effects of sulfur containing chemopreventive agents, including allyl sulfides and isothiocyanates, on human redox networks...

Keywords: A549 cells, allyl sulfides, enzyme inhibition, isothiocyanates, redox networks, transcript levels,

01/2007 | Biological Chemistry, Walter de Gruyter