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You are here: Home :: Keyword index :: α-Is bis atr :: 7-hydroxy divanillyl butyrolactol lignans - ?- und ?-Thalassämien 8-oxoGuo

Items for "8-oxoGuo"

Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA

Human A549 lung epithelial cells were challenged with 18O-labeled hydrogen peroxide ([18O]-H2O2), the total RNA and DNA extracted in parallel, and analyzed for 18O-labeled 8-oxo-7,8-dihydroguanosine ([18O]-8-oxoGuo) and 8-oxo-7,8-dihydro-2?-deoxyguanosine ([18O]-8-oxodGuo) respectively, using high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-MS/MS)...

Keywords: A549 cells, electrospray ionization, Mass spectrometry, oxidative stress, 8-oxodGuo, 8-oxoGuo

04/2005 | Biological Chemistry, Walter de Gruyter
A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration

We developed a novel method for the simultaneous extraction and analysis of total tissue RNA and DNA to quantify the RNA and DNA oxidation products 8-oxo-7,8-dihydroguanosine and 8-oxo-7,8-dihydro-2?-deoxyguanosine using HPLC coupled to electrochemical detection (HPLC-ECD)...

Keywords: doxorubicin, free radical, nucleic acids, oxidative stress, 8-oxodGuo, 8-oxoGuo

01/2006 | Biological Chemistry, Walter de Gruyter