Items for "5-fluorouracil"

Identification of three novel mutations in the dihydropyrimidine dehydrogenase gene associated with altered pre-mRNA splicing or protein function

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of the pyrimidine bases uracil and thymine, as well as of the widely used chemotherapeutic drug 5-fluorouracil (5FU)...

Keywords: dihydropyrimidine dehydrogenase, DPYD, 5-fluorouracil, pharmacogenetics, pyrimidines, thymine, uracil