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Bernd Huppertz, Gisela Gauchel, Heribert Feiertag, Hermann Schweizer, Horst Krieger, Francois Richter, Helmut Heinz, Joerg Blanke, Markus Gastpar, Ruprecht Keller

Urine labeling with orally applied marker substances in drug substitution therapy

The compliance of 581 drug addicts attending six methadone substitution outpatient clinics was determined over a period of 18 months. Urine from these patients was labeled following oral administration of low molecular weight polyethylene glycols as marker substances. These substances were measured in approx. 5800 urine samples. A protocol for applying marker substances and ways to prevent substitution of urine samples were evaluated. Normal values for marker substances in urine were determined. The results suggest that this labeling procedure is a new diagnostictool to prevent manipulation of urine samples by drug addicts receiving substitution therapy.

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 42, 06/2004
Pages: 621 - 626

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