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Marcus Dittrich, Ingvild Birschmann, Christiane Stuhlfelder, Albert Sickmann, Sabine Herterich, Bernhard Nieswandt, Ulrich Walter, Thomas Dandekar

Understanding platelets. Lessons from proteomics, genomics and promises from network analysis

New large-scale analysis techniques such as bioinformatics, mass spectrometry and SAGE data analysis will allow a new framework for understanding platelets. This review analyses some important options and tasks for these tools and examines an outline of the new, refined picture of the platelet outlined by these new techniques. Looking at the platelet-specific building blocks of genome, (active) transcriptome and proteome (notably secretome and phospho-proteome), we summarize current bioinformatical and biochemical approaches, tasks as well as their limitations. Understanding the surprisingly complex platelet regarding compartmentalization, key cascades, and pathways including clinical implications will remain an exciting and hopefully fruitful challenge for the future.

Thrombosis and Haemostasis, Schattauer

Print ISSN: 0340-6245
Volume: 94, 11/2005
Pages: 916 - 925

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