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R. H. Regev, O. Stolar, A. Raz, T. Dolfin

Treatment of severe cholestasis in neonatal Dubin-Johnson syndrome with ursodeoxycholic acid

We report a case of Dubin-Johnson Syndrome in a neonate presenting with severe direct hyperbilirubinemia, which failed to respond to phenobarbital treatment. Ursodeoxycholic Acid added to therapy was well tolerated, and resulted in declining bilirubin concentration. We suggest ursodeoxycholic acid in treatment for Dubin- Johnson Syndrome with severe direct hyperbilirubinemia presenting in the neonatal age.

Journal of Perinatal Medicine, Walter de Gruyter

Print ISSN: 1619-3997
Volume: 30, 04/2002
Pages: 185 - 187

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