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Jerry P. Melchor, Sidney Strickland

Tissue plasminogen activator in central nervous system physiology and pathology

Although conventionally associated with fibrin clot degradation, recent work has uncovered new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central nervous system physiology and pathology. This extracellular proteolytic cascade has been shown to have roles in learning and memory, stress, neuronal degeneration, addiction and Alzheimers disease. The current review considers the different ways tPA functions in the brain.

Thrombosis and Haemostasis, Schattauer

Print ISSN: 0340-6245
Volume: 93, 04/2005
Pages: 655 - 660

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