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Alun Price, Christine Burgin, Martin Cruise

Stability of Cardiac Troponins and CK-MB Mass Isoenzyme

The stability of an analyte can have an important influence on its diagnostic performance and therefore should be documented before an analyte is introduced into routine practice. The stability of creatine kinase MB isoenzyme (CK-MB), troponin I and troponin T was studied by incubating samples at temperatures between 26° C and 39° C for periods up to 5400 min. Arrhenius plots were made which showed that all three proteins demonstrated a rapid decrease in stability between 15° C and 20° C. The activation energies for CKMB, troponin I and troponin T were 7.7, 6.34 and 6.34 cal/mol, respectively.

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 38, 11/2000
Pages: 1159 - 1160

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