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Thomas Bertsch, Sandra Kuehl, Frank Muehlhauser, Silke Walter, Britta Hodapp, Siegbert Rossol, Joachim Schmeck, Andreas Ragoschke, Sandra Schütt, Michael Fritzinger, Peter Horn, Peter Vajkoczy, Martina Wendel-Wellner, Klaus Faßbender

Source of Endothelin-1 in Subarachnoid Hemorraghe

Endothelin-1 is the most potent vasoconstrictor known to date. This peptide is believed to play a pathophysiological role in the development of vasospasm, the most important complication of subarachnoid hemorrhage (SAH). In the present study we investigated the release of endothelin-1 in SAH and analyzed the cellular source of this peptide. At a protein and mRNA level we were able to show that endothelin-1 is produced by mononuclear leukocytes. Complementary in vitro studies revealed that aging and subsequent hemolysis of blood is sufficient to induce production of endothelin-1 by mononuclear leukocytes. Thus, cerebrospinal fluid-derived mononuclear leukocytes are a source of endothelin-1 in patients suffering from SAH. This finding may have important therapeutic implications as anti-leukocyte strategies could prevent cerebrovascular complications in SAH patients.

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 39, 04/2001
Pages: 341 - 345

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