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Erhard Hofer, Bernhard Schweighofer
Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis
Keywords: Angiogenesis and inhibitors,signal transduction,endothelial cells
New vessel formation during development and in the adult is triggered by concerted signals of largely endothelial-specific receptors for ligands of the VEGF, angiopoietin and ephrin families. The signals and genes induced by these receptors operate in the context of additional signals transduced by non-endothelial specific growth factor receptors, inflammatory cytokine receptors as well as adhesion molecules. We summarize here available data on characteristic signaling of the VEGF receptor-2 and the current state of knowledge regarding the additional different receptor tyrosine kinases of the VEGF, Tie and Ephrin receptor families. Furthermore, the potential cross-talk with signals induced by other growth factors and inflammatory cytokines as well as the modulation by VE-cadherin is discussed.
Thrombosis and Haemostasis, Schattauer
Print ISSN: 0340-6245
Volume: 97, 03/2007
Pages: 355 - 363