Science.Online
Search
Publisher and Institutes
Akademie Verlag
Deutsches Institut für Urbanistik
Oldenbourg Wissenschaftsverlag
Walter de Gruyter
Schattauer
You are here: Home :: Area NEM :: Medical science :: Human medicine
 
Abel Lpez-Bermejo, Ildefonso Hernndez-Aguado, Inmaculada Jarrn Vera, Mnica Recasens, Eduardo Esteve, Roser Casamitjana, Wifredo Ricart, Jos Manuel Fernndez-Real

Sex-specific, independent associations of insulin resistance with erythrocyte sedimentation rate in apparently healthy subjects

Keywords: Diabetes mellitus, obesity, inflammation, insulin sensitivity, erythrocyte sedimentation rate

Insulin resistance and erythrocyte sedimentation rate (ESR, a non-specific marker of inflammation) are known risk factors for cardiovascular disease. Although obesity is associated with increased ESR, it is unclear whether insulin resistance is associated with ESR in humans. The relationship between insulin resistance and ESR was studied in a cross-sectional, health-area based study of 140 (89 men and 51 women) apparently healthy Caucasians subjects. ESR, additional inflammatory markers [soluble tumor necrosis alpha receptors 1 and 2 (sTNFR1 and sTNFR2); C-reactive protein (CRP)], and insulin sensitivity (SI, frequently sampled intravenous glucose tolerance test with minimal model analysis) were assessed in all subjects. An interaction with sex was documented in the relationship between ESR and both insulin resistance and obesity (p < 0.05), as log ESR correlated with log SI in men (r = 0.29, p = 0.009), but not in women (r = 0.14, p = 0.33), and correlated with body mass index (BMI) in women (r = 0.49, p = <0.0001), but not in men (r = 0.15, p = 0.16). On multivariate analyses, these associations proved to be independent of known covariates, such as age, hematocrit, smoking and additional inflammatory markers in both men and women. In a replication study, variables independently associated with ESR were also insulin resistance (homeostasis model assessment) in men and obesity markers (either BMI or fat mass) in women. In conclusion, ESR is independently associated with either insulin resistance or obesity in a sex-specific manner. These findings contribute to explain the known relationship of this inflammatory marker with cardiovascular disease.

Thrombosis and Haemostasis, Schattauer

Print ISSN: 0340-6245
Volume: 97
Pages: 240 - 244

Show full article (external site)

Show all available items of this journal