SearchPublisher and Institutes
You are here: Home :: Area NEM :: Medical science :: Human medicine
Ahmet Kale, Gokhan Bayhan, Ahmet Yalinkaya, Murat Yayla
The use of recombinant factor VIIa in a primigravida with Glanzmann’s thrombasthenia during delivery
Keywords: Glanzmann?s thrombasthenia, platelet transfusion, postpartum hemorrhage, pregnancy, recombinant human coagulation factor VIIa (rFVIIa)
Glanzmann’s thrombasthenia is an inherited hemorrhagic disorder characterized by a severe reduction in, or absence of, platelet aggregation in response to multiple physiologic agonists due to qualitative or quantitative abnormalities of platelet glycoprotein IIb-IIIa. Glanzmann’s thrombasthenia is characterized by potentially major mucocutaneous bleeding and prolonged bleeding time. Platelet counts, platelet morphology, prothrombin, and activated thromboplastin times are all within normal ranges in patients with Glanzmann’s thrombasthenia. Pregnancy and delivery are rare in Glanzmann thrombasthenia patients and have been associated with immediate postpartum hemorrhage. We describe the peripartum management of a 31-year-old primipara with Glanzmann’s thrombasthenia who underwent spontaneous vaginal delivery. Four units of single-donor platelets, two units of packed red blood cells, 36 µg/kg recombinant human coagulation Factor VIIa (rFVIIa) were given during peripartum management.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 32, 09/2004
Pages: 456 - 458