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Franck Ceppa, Stephane Gidenne, Alain Benois, Eleonore Fontan, Pascal Burnat

Rapid Identification of Atypical Variant of Plasma Butyrylcholinesterase by PCR

Human butyrylcholinesterase is the enzyme responsible of mivacurium and succinylcholine metabolism, which may be significantly impaired when mutation Asp70Gly is found in patients. We describe a simple PCR method for the detection of this variant. Thirteen out of sixteen patients tested after prolonged apnea were positive for the presence of this mutation (50.0% homozygotes and 31.3% heterozygotes), suggesting that this test contributes to the explanation of some clinical events and to their prevention in relatives of these patients.

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 40, 08/2002
Pages: 799 - 801

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