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Dharmarai Pillay, Anil A. Chuturgoon, Elena Nevines, Thavrin Manickum, Walter Deppe, Michael F. Dutton

The Quantitative Analysis of Zearalenone and Its Derivatives in Plasma of Patients with Breast and Cervical Cancer

Zearalenone (6-[10-hydroxy-6-oxo-trans-1-undecenyl]-?-resorcylic acid-?-lactone), a mycotoxin produced in corn, is able to adopt a conformation which sufficiently resembles 17?-oestradiol to allow it to bind to the oestrogen receptor in target cells of the body and exert (agonist) oestrogenic action. We adopted an analytical approach to isolate and quantify the mycotoxin and its derivatives using high-performance liquid chromatography and gas chromatography-mass spectrometry. In this study, the quantity of zearalenone and its congeners (?-zearalenol and ?-zearalenol) present in the plasma of patients with breast (n=28) and cervical carcinoma (n=54) were compared with levels in patients presenting with other diagnoses (n=26) and healthy volunteers (n=24). There were no significant differences between the groups in the levels of zearalenone and its congeners, using analysis of covariance (0.2

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 40, 09/2002
Pages: 946 - 951

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