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Ali Al-Shanqeeti, Astrid van Hylckama Vlieg, Erik Berntorp, Frits R. Rosendaal, George J. Broze Jr.

Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis

To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.

Thrombosis and Haemostasis, Schattauer

Print ISSN: 0340-6245
Volume: 93, 03/2005
Pages: 411 - 413

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