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Henry Vlzke, Daniel M. Robinson, Volker Kleine, Sabine Hertwig, Christian Schwahn, Rita Grimm, Lothar Eckel, Rainer Rettig

Preoperative plasma fibrinogen levels predict mortality after coronary artery bypass grafting

This study was designed to investigate whether plasma fibrinogen levels as well as the -fibrinogen -455 G/A genotype are associated with outcome after coronary artery bypass graft (CABG) operation. We enrolled 249 consecutive CAD patients one day before they underwent a CABG operation. Data from 220 patients with available plasma fibrinogen levels were analyzed. The primary end-point was total mortality, the secondary end-point mortality from cardiac causes or the need for myocardial revascularization. The 2-year total mortality was 9.1% in the entire cohort. Multivariable analysis revealed an independent relationship between the primary end-point and preoperative plasma fibrinogen levels but not the -fibrinogen -455 G/A genotype. Neither preoperative plasma fibrinogen levels nor the -fibrinogen -455 G/A genotype could predict the secondary end-point. We conclude, that elevated preoperative plasma fibrinogen levels, but not the -fibrinogen -455 G/A genotype predict the total mortality after CABG operation.

Thrombosis and Haemostasis, Schattauer

Print ISSN: 0340-6245
Volume: 89, 05/2003
Pages: 885 - 891

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