L. Burd, R. Severud, M. G. Klug, J. Kerbeshian
Prenatal and perinatal risk factors for Tourette disorder
Aims: To identify pre- and perinatal risk factors for
Tourette disorder.
Methods: Case control study. We matched names of patients
who met DSM criteria for Tourette disorder with
their birth certificates. For each case five controls were
selected. The controls were matched by sex, year and
month of birth.
Results: Univariate analysis of the 92 cases and the 460
matched controls identified 4 risk factors; one categorical
variable–trimester prenatal care begun and 3 continuous variables 2 apgar score at 5 minutes, month prenatal began
and number of prenatal visits. Logistic modeling to
control for confounding produced a three variable model
(apgar score at 5 minutes (OR 5 1.31), number of prenatal
visits (OR 5 .904) and fathers age (OR 5 .909). The
model parameters were: ?2 5 19.76; df 5 3; p < .001.
Conclusions: This is an inexpensive methodology to
identify potential risk factors of patients with Tourette
disorder and other mental illness.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 27, 09/1999
Pages: 295 - 302
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