SearchPublisher and Institutes
You are here: Home :: Area NEM :: Medical science :: Human medicine
Georgios Karanikas, Konstantin Zedwitz-Liebenstein, Harald Eidherr, Matthias Schuetz, Robert Sauerman, Robert Dudczak, Stefan Winkler, Ingrid Pabinger, Kurt Kletter
Platelet kinetics and scintigraphic imaging in thrombocytopenic malaria patients
Thrombocytopenia is a common occurrence in acute malaria. It is attributed, among other factors, to excessive splenic platelet pooling and a shortened platelet lifespan. The aim of our study was to evaluate the platelet kinetics and sequestration site by isotopic studies in uncomplicated malaria-induced thrombocytopenia. Seven thrombocytopenic malaria patients (74,00036,000 platelets/l) were included in the study. Autologous 111In-labeled platelet scintigraphy was performed up to 96 hours (h) post injection (p.i.) to evaluate the platelet sequestration site. Late sequestration for the spleen (S) and the liver (L) was analyzed according to the following activity ratios: S (spleen count on the last day of the platelet lifespan / spleen count at 30 min) and L (liver count on the last day of the platelet lifespan / liver count at 30 min). Additionally, platelet survival studies were performed. A normal late sequestration (S: 0.950.06 and L: 1.040.08; normal values, S and L: 10.2.) was observed in all of our patients. The platelet lifespan was reduced (1 to 4 days; normal range, 79 days), recovery was normal (mean, 636%; normal range, 5575%), and the turnover rate was enhanced (mean, 95,00080,000/l/day; normal value, 35,0004,500/l/ day). According to the results of scintigraphy, the sequestration site by uncomplicated malaria-induced thrombocytopenia appears to be non-splenic and/or hepatic, yet diffuse.
Thrombosis and Haemostasis, Schattauer
Print ISSN: 0340-6245
Volume: 91, 03/2004
Pages: 553 - 557