D.P. Nguyen, S. Gerber, P. Hohlfeld, G. Sandrine, S.S. Witkin
Mycoplasma hominis in mid-trimester amniotic fluid: relation to pregnancy outcome
Objective: The relationship between detection of Mycoplasma
hominis in mid-trimester amniotic fluid and subsequent
pregnancy outcome was investigated.
Study design: Amniotic fluids from 456 women of European
background who underwent a transabdominal
amniocentesis at weeks 15–17 of pregnancy were tested
for M. hominis by polymerase chain reaction (PCR). The
amplicons were hybridized to an internal probe and
detected by ELISA. Pregnancy outcomes and clinical
data were subsequently obtained.
Results: M. hominis were identified in 29 (6.4%) of the
amniotic fluids. The rate of preterm labor in women positive
for M. hominis (14.3%) was higher than in the negative
women (3.3%) (p=0.01). Similarly, a spontaneous
preterm birth with intact membranes occurred in 10.7%
of the M. hominis-positive women as opposed to only
1.9% of the negative women (p=0.02). The presence of
this mycoplasma was not correlated with fetal chromosomal
aberrations, intrauterine growth restriction or
preeclampsia.
Conclusions: Detection of M. hominis in second-trimester
amniotic fluids can identify women at increased risk
for subsequent preterm labor and delivery.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 32, 07/2004
Pages: 323 - 326
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