SearchPublisher and Institutes
You are here: Home :: Area NEM :: Medical science :: Human medicine
Xiao Xin, Zhou Xiaoguang, Zhu Ninghu, Luo Youtong, Xu Liumei, Zhou Boping
Mother-to-infant vertical transmission of transfusion transmitted virus in South China
Keywords: genetics, infant, nested polymerase chain reaction, pregnancy, transfusion transmitted virus, vertical transmission
A nested PCR was used to detect TTV DNA in serum from 490 mother-infant pairs to determine the rate of vertical transmission of TTV in Guangzhou City, P.R. China. TTV DNA was positive in 87 mothers and 12 of their babies, giving a prevalence of 17.8% in pregnant women and a mother-to-child transmission rate of 13.8%. In eight mother-infant pairs, TTV DNA nucleotide sequences from the mothers and their corresponding infants were identical. The homology of Guangzhou TTV and Japanese TTV ranged from 85.3%–98.2% at nucleotide level. TTV infection is common in pregnant women in South China and vertical transmission can occur. Guangzhou’s and Japanese TTV isolates belong to the same genotype.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 32, 09/2004
Pages: 404 - 406