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Diana Bonderman, Johannes Jakowitsch, Christopher Adlbrecht, Michael Schemper, Paul A. Kyrle, Verena Schnauer, Markus Exner, Walter Klepetko, Meinhard P. Kneussl, Gerald Maurer, Irene Lang

Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension

Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by organized thromboemboli that obstruct the pulmonary vascular bed. Although CTEPH is a serious complication of acute symptomatic pulmonary embolism in 4% of cases, signs, symptoms and classical risk factors for venous thromboembolism are lacking. The aim of the present study was to identify medical conditions conferring an increased risk of CTEPH. We performed a case-control-study comparing 109 consecutive CTEPH patients to 187 patients with acute pulmonary embolism that was confirmed by a high probability lung scan. Splenectomy (odds ratio=13, 95% CI 2.7127), ventriculo-atrial (VA-) shunt for the treatment of hydrocephalus (odds ratio=13, 95% CI 2.5129) and chronic inflammatory disorders, such as osteomyelitis and inflammatory bowel disease (IBD, odds ratio=67, 95% CI 7.98832) were associated with an increased risk of CTEPH.

Thrombosis and Haemostasis, Schattauer

Print ISSN: 0340-6245
Volume: 93, 03/2005
Pages: 512 - 516

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