Nilgün Öztürk Turhan, Aysun Karabulut, Bahattin Adam
Maternal serum interleukin 6 levels in preterm labor: prediction of admission-to-delivery interval
Objective: To evaluate the diagnostic value of maternal
serum interleukin 6 (IL-6), C-reactive protein (CRP)
levels and white blood cell (WBC) count for the prediction
of preterm labor and length of admission-to-delivery
interval in patients with preterm labor.
Methods: Maternal serum IL-6, CRP and WBC count
were prospectively determined in eighty-two patients in
preterm labor and 21 controls. Data was analyzed in
study and control groups, and for the assessment of clinical
and laboratory risk factors in the prediction of admission-to-delivery interval in the study group.
Results: Maternal serum IL-6 levels were significantly
higher in the study group than controls. The IL-6 value
associated with the highest percent of true positives and
true negatives for the prediction of preterm labor was
5 pg/ml. The area under curve of maternal IL-6 was significantly
higher than the area under curve of of CRP
and WBC count. In the study group maternal serum IL-6 levels were significantly higher in patients delivered
within 2 and 7 days than the nondelivering ones and a
cut off value of 8.3 pg/ml was determined for estimation
of preterm delivery.
Conclusion: Maternal serum IL-6 is a reliable marker
in the prediction and management of preterm labor and
delivery.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 28, 04/2000
Pages: 133 - 139
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