Ö. Öktem, N. Dedeo?lu, Y. Oymak, D. Sezen, L. Köksal, T. Pekin, H. Gökaslan, Z.N. Kavak
Maternal serum, amniotic fluid and cord leptin levels at term: their correlations with fetal weight
Aims: To investigate the relationship between fetal
weight and leptin levels in maternal serum, amniotic fluid
and umbilical cord.
Methods: Forty pregnant women presenting for antenatal
care at early weeks of gestation were enrolled for
the study. Maternal and cord blood samples for leptin
measurement were obtained at birth. Amniotic fluid samples
were recovered by amniotomy performed during
labor. Maternal body mass index and placental weight
were also recorded. Leptin measurement was carried out
using the ELISA method. Spearman's correlation test
was used for comparison of non-parametric data.
Results: Leptin concentration in venous cord blood correlated
significantly with birth weight and placental
weight whereas maternal serum and amniotic fluid leptin
levels did not show correlation with birth weight. There
were no significant correlations between leptin levels in
maternal serum, cord blood and amniotic fluid.
Conclusion: We conclude that lack of correlation
between leptin levels in mother, cord and amniotic fluid
suggest that these compartments may be non-communicating
separate units or have different mechanisms regulating
leptin synthesis or degradation, and that leptin in
maternal blood and amniotic fluid may not have a direct
effect on fetal growth but rather a different role in
pregnancy.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 32, 05/2004
Pages: 266 - 271
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