A. Erdem, M. Erdem, Ö. Himmetoglu, G. Yildirim, M. Arslan
Maternal and fetal plasma endothelin levels in intrauterine growth restriction:
relation to umbilical artery Doppler flow velocimetry
The objective of this study was to examine maternal and
fetal endothelin-1 (ET-1) in pregnancies complicated
with intrauterine growth restriction (IUGR) and to correlate
these data with umbilical artery Doppler flow velocity
waveforms (FVW). Higher mean maternal
(13.8±6,4 vs 9.2±3,4 pmol/L, p < 0.05 ) and fetal
(18.5±9.6 vs 11.7±6.9 pmol/L, p < 0.05) ET-1 levels were
found in pregnancies complicated with IUGR than in
controls. Fetal ET-1 level was related to birth weight percentile
for gestational week. Maternal and fetal ET-1
concentrations were not related to umbilical artery
Doppler flow S/D ratio, PI and RI. Maternal or fetal ET-
1 concentrations were also not related to umbilical artery
pH, PO2 and PCO2. Pregnancy-induced hypertenXsion was significantly associated with an elevated fetal
and maternal ET-1 concentration. In conclusion, increased
production and secretion of ET-1 may play a role
in the pathophysiology of idiopathic IUGR. Over-production
of ET-1 in IUGR is not associated with increased
placental resistance as reflected in abnormal umbilical
artery Doppler FVW.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 31, 01/2003
Pages: 52 - 59
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