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Natàlia Ferré, Jordi Camps, Joan Fernández-Ballart, Victoria Arija, Michelle M. Murphy, Judit Marsillach, Jorge Joven

Longitudinal changes in serum paraoxonase-1 activity throughout normal pregnancy

Keywords: Oxidation, paraoxonase-1, pregnancy, vitamin C

The aim of this study was to investigate the longitudinal changes in serum paraoxonase-1 (PON1) activity from preconception throughout normal pregnancy and their relationships with maternal dietary vitamin C and E intake. The study was performed in 35 women (studied at preconception, at 8, 20 and 32 weeks of pregnancy, and at labour). PON1 activity decreased significantly from 145.8 (109.8–198.8) U/L at preconception to 111.1 (85.3–179.9) U/L (p<0.01) at 32 weeks and 100.4 (54.7–171.4) U/L (p<0.001) at labour. There was a direct association between vitamin C intake and PON1 at week 32 (p=0.018). We conclude that adequate vitamin C intake in pregnant women may merit consideration, since vitamin C supplementation has proved beneficial in the prevention of preeclampsia in women at increased risk of this condition.

Clin Chem Lab Med 2006;44:880–2.

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 44, 07/2006
Pages: 880 - 882

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