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Thomas P. J. Linsinger, Anton M. H. P. van den Besselaar, Armando Tripodi

Long-term stability of relationships between reference materials for thromboplastins

Keywords: Thromboplastin, reference material, stability, calibration

Reference materials for thromboplastins are available from the World Health Organization (WHO) and the European Commission (EC). The long-term stability of the reference materials is an essential requirement and must be monitored. The relationship between two reference materials for rabbit thromboplastin, i.e. ERM-AD149 (EC) and RBT/90 (WHO), has been monitored in the period 1996-2002. No significant trend with time was detected. In addition, the relationship between ERM-AD149 and the reference material for bovine thromboplastin (i.e. OBT/79) has been determined in 1994 and in 2005 in multicentre studies (n = 11 and n = 9, respectively). No significant changes were observed in the relationships between these reference materials when all results were included (5% significance level).

Thrombosis and Haemostasis, Schattauer

Print ISSN: 0340-6245
Volume: 96, 08/2006
Pages: 210 - 214

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