D.-C. Fischer, M. Winkler, P. Ruck, D. Poth, B. Kemp, W. Rath
Localization and quantification of adhesion molecule expression in the lower uterine segment during premature labor
Aims: To investigate localization and concentration of
adhesion molecules in the human lower uterine segment
during preterm parturition.
Methods: In a prospective study biopsy specimens
from the lower uterine segment of 43 patients undergoing
cesarean section at 24 + 0 to 36 + 4 weeks' gestation
were immunostained for intercellular adhesion
molecule-1, endothelial leukocyte adhesion molecule-1,
vascular cell adhesion molecule-1, and platelet endothelial
cell adhesion molecule-1, and the concentrations
measured by enzyme immunoassay. The results were
analyzed in relation to the degree of cervical dilatation
(< 2 cm, 2 – < 4 cm, ? 4 cm) and duration of labor
(? 6 h, > 6–12 h; > 12 h).
Results: Intercellular adhesion molecule-1 and platelet
endothelial cell adhesion molecule-1 were strongly
expressed by capillary endothelium, endothelial leukocyte
adhesion molecule-1 and vascular cell adhesion
molecule-1 to only a minor degree. Intercellular adhesion
molecule-1 concentration was greater at ? 4 cm
dilatation than at 2– < 4 cm and after > 12 h labor
than after ? 6 h. Endothelial leukocyte adhesion
molecule-1 concentration was greater after >12 h
than after ? 6 h.
Conclusions: Premature labor is associated with up-regulation
of adhesion molecules in the lower uterine segment.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 29, 11/2001
Pages: 497 - 505
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