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Michiel J. B. Kemme, Jacobus Burggraaf, Rik C. Schoemaker, Adam F. Cohen, Cornelis Kluft, Stanley Chia, David J. Webb, David E. Newby

Local tissue factor pathway inhibitor release in the human forearm

Nineteen healthy men received unilateral brachial artery infusions of either unfractioned heparin (0.3100 IU/min), saline or the endothelium-dependent vasodilators substance P (28 pmol/min) and bradykinin (1001000 pmol/min), and the endothelium-independent vasodilator sodium nitroprusside (28 g/min). Heparin caused a dose-dependent increase in plasma TFPI concentrations in both arms (ANOVA, p <0.0001). Estimated net forearm TFPI release was 7 16, 29 20 and 138 72 ng/100 mL tissue/min during 10, 30 and 100 IU/min of heparin respectively (ANOVA, p <0.0001). Compared to the systemic circulation, the forearm sensitivity to heparin induced TFPI release was 3.6-fold lower (166 67 ng/IU vs. 596 252 ng/IU: t-test, p = 0.004). Substance P, bradykinin and sodium nitroprusside all caused substantial dose-dependent increases in blood flow (ANOVA, p <0.001 for all) without affecting plasma TFPI concentrations. There are important regional differences in endothelial TFPI release, with the forearm circulation being relatively insensitive to heparin.

Thrombosis and Haemostasis, Schattauer

Print ISSN: 0340-6245
Volume: 89, 03/2003
Pages: 438 - 445

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