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Barbro sterlund, Christina Jern, Helene Seeman-Lodding, Gran Johansson, Sren Hggmark, Michael Broom, Bjrn Biber
Intracoronary 2 receptor activation induces dynamic local t-PA release in the pig
To investigate 2 -adrenergic agonist-mediated effects on coronary fluxes of local fibrinolytic factors, healthy anaesthetised and instrumented pigs (n=10) were studied during infusion of isoprenaline (IPR) into the left main coronary artery. Coronary net fluxes of total t-PA antigen, active t-PA and total PAI-1 antigen were determined at baseline and at 3, 5, 7 and 10 minutes of IPR infusion. During IPR, net release of total t-PA increased in a biphasic pattern with transiently high levels at 3 (+440 %) and 7 minutes (+620%) and returned towards baseline at 10 minutes. Net coronary release of active t-PA increased with maximum levels at 3 minutes (+50%). Baseline coronary net flux of total PAI -1 showed a decrease which was most pronounced at 10 minutes. To conclude, a fast 2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile.
Thrombosis and Haemostasis, Schattauer
Print ISSN: 0340-6245
Volume: 90, 11/2003
Pages: 796 - 802