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Rodrig Marculescu, Gottfried Sodeck, Hans Domanovits, Gerhard Hobusch, Markus Exner, Harald Heinzl, Kurt Huber, Christine Mannhalter, Erich Minar, Oswald Wagner, Martin Schillinger
Interleukin-1 gene cluster variants and abdominal aortic aneurysms: a matched case control study
Inflammation is a key factor in the pathogenesis of abdominal aortic aneurysms (AAA). Interleukin 1 (IL-1), a fundamental regulator of the inflammatory cascade, has been shown to be involved in this process. Several functional polymorphisms in the IL-1 gene cluster are known. In this matched case-control study, we investigated a potential association between six genetic variants in IL-1 and IL-1 receptor antagonist (IL-1 RN) with AAA. We enrolled 405 individuals, 135 consecutive patients with AAA were individually age- and sex-matched to 270 patients with coronary artery disease (CAD). Traditional cardiovascular risk factors and IL-1 genotypes were determined, and the distribution of six single nucleotide polymorphisms were compared between patients and controls by multivariable conditional logistic regression analysis: IL-1A (-889) C > T, IL-1A (+4845) G > T, IL-1B (-511) C > T, IL-1B (-31) C > T, IL-1B (+3954) C > T and IL-1RN (+2018) C > T. IL-1A (-889) C > T and IL-1A (+4845) G > T (kappa 0.98, 95% CI 0.96 to 1.00), and IL-1B (-511) C > T and IL-1B (-31) C > T (kappa 0.98, 95% CI 0.96 to 1.00) were closely linked, therefore IL-1A (-889) C > T and IL-1B (-31) C > T were not considered for further analyses. None of the 4 remaining polymorphisms showed a significant association with AAA: IL-1RN (+2018) C > T (p = 0.061), IL-1B (+3954) C > T (p = 0.51), IL-1B (-511) C > T (p = 0.61) and IL-1A (+4845) G > T (p = 0.81). No significant first-degree interactions between the genetic variants and AAA were detected. In conclusion, these six genetic variants in the interleukin-1 gene cluster do not seem to play a clinically relevant role in the pathogenesis of AAA, although we cannot rule out the existence of higher degree gene-gene or gene-environment interactions.
Thrombosis and Haemostasis, Schattauer
Print ISSN: 0340-6245
Volume: 94, 09/2005
Pages: 646 - 650