B. Il Kim, H. E.Lee, C.W. Choi, H.S. Jo, E. H. Choi, Y. Y. Koh, J.-H. Choi
Increase in cord blood soluble E-selectin and tracheal aspirate neutrophils at birth and the development of new bronchopulmonary dysplasia
Aim: To test the hypothesis that preterm infants who
develop new type of bronchopulmonary dysplasia BPD
have higher cord blood sE-selectin levels and neutrophil
counts in the tracheal aspirate at birth than those who
do not.
Methods: The relationship between cord blood sE-selectin
levels and neutrophil counts in the tracheal aspirate
at birth and the development of BPD was examined in
30 preterm infants. Levels of sE-selectin and neutrophil
counts were measured by specific immunoassay and by
cytospin analysis.
Results: Median cord blood levels of sE-selectin and
neutrophil counts in the tracheal aspirate at birth were
higher in preterm infants who developed BPD than in
those who did not (P<0.01 for each). These differences
persisted significantly after adjusting for the effects of
gestational age and the presence of histologic chorioamnionitis
and patent ductus arteriosus PDA (P<0.01 for
each).
Conclusion: Fetal pulmonary inflammation, as measured
by increased cord blood levels of sE-selectin and neutrophil
counts in the tracheal aspirate at birth, may be a
risk factor for the development of new BPD in preterm
infants. These results support the hypothesis that the
lung injury responsible for new BPD in preterm infants
can begin in the prenatal period and could be associated
with a fetal pulmonary inflammation.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 32, 05/2004
Pages: 282 - 287
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