Isaac Blickstein, Ran D. Goldman, Ram Mazkereth
Incidence and birth weight characteristics of twins born to mothers aged 40 years or more compared with 35-39 years old mothers: a population study
Objective: To compare the incidence of twin births and
their birth weight characteristics in mothers aged ? 40
years with those of mothers aged 35–39 years.
Methods: We used a population-based cohort of Israeli
twins delivered between 1993–98 to compare birth
weight characteristics of 510 and 2102 twin pairs delivered
to mothers aged ? 40 years (cases) and 35–39
years (controls), respectively.
Results: The incidence of twin mothers aged 40 years
or more increased 50% during the study period, ten
times more than mothers aged 35–39. There were significantly
more nulliparas (P < .001, OR 1.54, 95% CI
1.2, 1.9) and more para ? 4 (P< .004, OR 1.38, 95%
CI 1.1, 1.7) among older mothers. Irrespective of parity,
there were no significant differences between mean
twin birth weight, total twin birth weight < 3000 g,
3000–4999 g, and ? 5000 g, and frequencies of very
low birth weight neonates.
Conclusions: Twin birth at the age of ? 40 years is
significantly more likely among either nulliparas or para
? 4. Birth weight characteristics of twins delivered to
mothers aged ? 40 years are not different from those
delivered to 35–39 years old mothers.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 29, 04/2001
Pages: 128 - 132
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