W. Göpel, K. Fehlau, M. Kohl, C. Schultz, J. Möller
HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams
Objective: In cohorts of infants with proven neonatal
alloimmune thrombocytopenia (NAIT) an unusual high
rate of preterm infants has been reported, raising the
question of whetherNAIT contributes to the high rate of
intracranial hemorrhage in preterm infants.
Methods: We genotyped the HPA-1-allele in a large
cohort of term (n = 205) and very low birth weight infants
(VLBW-infants, n = 299) with polymerase-chain-reaction
and restriction enzyme digestion.
Results: HPA-1a/b is the only fetal HPA-1-genotype in
which alloimmunization and NAIT could occur. Genotype
distribution did not differ between term and
VLBW-infants (p = 0.26). Furthermore, neither HPA-1a/b genotype nor platelet count at birth were of significant
prognostic value in predicting subsequent intracranial
haemorrhage or death inVLBW-infants (p = 0.93
and p = 0.19 respectively).
Conclusion: Our data did not support the hypothesis
that routine screening of preterm infants or their
mothers for HPA-1-genotype is of additional value in
the care of these infants.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 30, 04/2002
Pages: 176 - 178
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