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Peter Van Leeuwen, Silke Lange, Daniel Geue, Dietrich Grönemeyer

Heart rate variability in the fetus: a comparison of measures

Keywords: approximate entropy, complexity, correlation analysis, fetal magnetocardiography, frequency domain, time domain

Background: In fetal surveillance, fetal heart rate changes are assessed using cardiotocography (CTG). Standard procedures used in the quantification of heart rate variability (HRV) are seldom applied as CTG does not deliver beat interval durations with the same accuracy as the electrocardiogram (ECG). Thus little is known about the interdependency of standard HRV measures prenatally.

Materials and methods: Using fetal magnetocardiography (FMCG: the magnetic equivalent of the fetal ECG), we investigated standard HRV measures in a homogenous group of 20 healthy fetuses. Ten HRV measures were analyzed in 60 five-minute RR interval time series derived from FMCG acquisitions (16^th–40^th week of gestation).

Results: Using regression analysis, we found a clear dependency on gestational age and mean RR interval for measures from the time and frequency domains as well as for a measure for complexity. Correlation analysis revealed a strong interdependency of the measures, in particular within the specific domains. An adequate description of fetal HRV may be achieved using the standard deviation from the time domain, the high frequency band (0.15–0.40 Hz) from the frequency domain and approximate entropy as a complexity measure.

Conclusion: The results indicate that different characteristics of fetal HRV are embedded in the different domains.

Biomedizinische Technik, Walter de Gruyter

Print ISSN: 0013-5585
Volume: 52, 02/2007
Pages: 61 - 65

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