Joseph P. McConnell, Earl L. Branum, Karla V. Ballman, Susan A. Lagerstedt, Jerry A. Katzmann, Allan S. Jaffe
Gender Differences in C-Reactive Protein Concentrations - Confirmation with Two Sensitive Methods
Two new automated, highly sensitive methods for the
measurement of C-reactive protein (CRP) were compared
using blood samples from active and retired
health care workers (116 males, 114 females). The regression
equation was y=1.115x?0.0267 for the Kamiya
K assay immunoturbidimetric method (x) vs. the
Behring BNII nephelometric method (y) with medians
(IQR) of 0.156 (0.081 to 0.276) and 0.150 (0.060 to 0.240)
mg/dl, respectively. Significant differences in hsCRP
values between males and females were observed
(p=0.013 and p=0.0018 for Behring and Kamiya methods,
respectively). This gender difference in CRP levels
was confirmed by analysis of serum samples from 1114
individuals (639 males and 475 females) obtained
through Mayo Medical Laboratories reference services,
which represents participants from across the
United States. The gender difference, which was confirmed
(p<0.0001), was independent of age differences
as assessed by multiple regression analysis. The observed
gender differences have important implications
for the establishment of cut-off points for cardiovascular
risk stratification.
Clinical Chemical Laboratory Medicine, Walter de Gruyter
Print ISSN: 1434-6621
Volume: 40, 01/2002
Pages: 56 - 59
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