Eda Vrta?nik-Bokal, Helena Meden-Vrtovec, Jo?ko Osredkar, Ivan Verdenik
Follicular Fluid Renin Concentration in
Patients with Polycystic Ovaries Treated with
Gonadotrophins in an in vitro Fertilisation
Programme
The initial hypothesis was that the follicular fluid prorenin
concentration was higher in women with polycystic
ovaries (PCO) compared to normally cycling
women stimulated by gonadotrophins. In a controlled
prospective study, 47 women undergoing in vitro fertilisation
(IVF) were enrolled: 20 women with PCO represented
the study group and 27 normally cycling
women the control group. Plasma prorenin, active
renin, serum oestradiol, and androstenedione concentrations
were measured on the day of human chorionic
gonadotrophin (HCG) administration and 36 hours after
HCG administration. Follicular fluid prorenin, active
renin, oestradiol, and androstenedione concentrations
from the dominant follicle and pooled follicles were
measured 36 hours after HCG administration. Plasma
prorenin concentration 36 hours after HCG administration
was significantly higher in the PCO group
(1867 ?U/l; range 1137–3162 ?U/l) than in controls
(860 ?U/l; range 433–1763 ?U/l) (p = 0.007). The follicular
fluid prorenin concentration in the dominant follicle
and in the pooled follicles was lower in the PCO group
(20190 ?U/l; range 11130–25955 ?U/l) than in controls
(46930 ?U/l; range 20671–66171 ?U/l) (p = 0.003). We
conclude that plasma prorenin concentrations in gonadotrophin-stimulated PCO cycles are augmented
due to numerous follicles. Lower follicular fluid
prorenin concentrations in women with PCO show
that the synthesis of prorenin in theca cells starts later
after HCG administration than in normally cycling
women.
Clinical Chemical Laboratory Medicine, Walter de Gruyter
Print ISSN: 1434-6621
Volume: 41, 05/2003
Pages: 663 - 667
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