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Jean Riou, Christian Godart, Mireille Mathis, Didier Hurtrel, Henri Wajcman, Claude Préhu, Josiane Bardakdjian
Evaluation of the Bio-Rad VARIANT? II HbA 2/HbA 1C Dual Program for measurement of hemoglobin concentrations and detection of variants
Keywords: hemoglobin A 2, hemoglobin F, sickle cell disease, thalassemia
In this work data obtained on the VARIANT? II hemoglobin analyzer using the Dual Kit elution system were compared to those obtained with the ?-Thalassemia Short Program. Since many laboratories still use an earlier model of the hemoglobin analyzer, the Variant? 1, these data were also compared to those obtained with the latter instrument. Our study is divided into two parts. The first is an evaluation of the precision of the VARIANT? II for determining the levels of hemoglobin (Hb)A 2 and Hb F. This was carried out for normal subjects, thalassemic patients and patients with HbS. The second part concerns the potential of this instrument in the presumptive identification of Hb variants.
Clinical Chemical Laboratory Medicine, Walter de Gruyter
Print ISSN: 1434-6621
Volume: 43, 04/2005
Pages: 237 - 243