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Celso Spada, Arício Treitinger, Marcellus Reis, Ivete Y. Masokawa, Júlio C. Verdi, Magali C. Luiz, Mariete V.S. Silveira, Osvaldo V. Oliveira, Cleonice M. Michelon, Sílvio Ávila-Junior, Ione D.O. Gil, Stephanie Ostrowsky
An Evaluation of Antiretroviral Therapy Associated with ?-Tocopherol Supplementation in HIV-infected Patients
In HIV-infected patients, an increase in the production of oxygen-reactive species (ROS) is observed, with a consequent reduction of plasma levels of antioxidants such as ?-tocopherol. The nuclear transcription factor-?B (NF-?B) is activated by a prooxidant state in the infected T cells through the release of its inhibitory subunit I-?B. The aim of the present work was to evaluate the behavior of hematological parameters and markers of anemia in HIV-infected patients who underwent antiretroviral therapy associated with 800 mg/day ?tocopherol supplementation. Blood samples were collected from supplemented (n=9) and not-supplemented (n=9) HIV-seropositive patients (n=18). We observed a decreased viral load in the ?-tocopherol-supplemented group (p<0.05); other changes, such as an increase in the CD4/CD8 ratio, in the hematocrit and in the hemoglobin concentration were also observed, though lacking statistical significance. We conclude that antiretroviral therapy in association with ?tocopherol (800 mg/day) supplementation is more effective in reducing viral load levels and also, possibly, in recovering other hematological parameters after a 60-day period of use.
Clinical Chemical Laboratory Medicine, Walter de Gruyter
Print ISSN: 1434-6621
Volume: 40, 06/2002
Pages: 456 - 459