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Michael Vogeser, Michael Weigand, Peter Fraunberger, Heike Fischer, Peter Cremer

Evaluation of the ADVIA® Centaur? TSH-3 Assay

An analytical evaluation of the thyroid stimulating hormone (TSH-3) assay on the Bayer ADVIA^® Centaur^TM immunoassay system was performed. General analytical requirements (linearity, resistance to typical interferences, absence of a carry-over effect) were fulfilled and reproducibility was satisfactory. Inter-assay coefficient of variation (CV) of a human serum pool with a concentration of 0.014 mU/l was 22.3%; at concentrations between 0.26 and 83 mU/l CV was below 6%. Method comparison study demonstrated close agreement of TSH results compared to those obtained with the Roche Elecsys^® 2010 TSH assay (ADVIA Centaur = 1.08 × Elecsys?0.18 mU/l; r=0.987; n=324). Handling and practicability of the ADVIA Centaur system proved to be convenient with a very high sample throughput. We conclude that the ADVIA Centaur TSH-3 assay meets requirements for clinical use.

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 38, 04/2000
Pages: 331 - 334

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