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Franca Pagani, Graziella Bonetti, Francesca Stefini, Mauro Panteghini

Evaluation of a Fully Automated Assay to Measure C-Telopeptide of Type I Collagen in Serum

The measurement of the degradation product of the C-telopeptide of type I collagen in serum (s-?CTX) has been evaluated in the form of an automated chemiluminometric assay. The between-day coefficients of variation ranged between 2.6 and 6.0% over the concentration range 0.12 to 3.25 ?g/l. The s-?CTX value correlated well with alternative serum C-telopeptide (r = 0.983) and urine deoxypyridinoline (r = 0.729) measurements. A significant inverse correlation was found between the s-?CTX measurement and creatinine clearance in patients with renal disease.

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 38, 11/2000
Pages: 1111 - 1113

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