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Yesim Ozarda Ilcol, Elif Basagan-Mogol, Mete Cengiz, Ismail H. Ulus
Elevation of serum cerebral injury markers correlates with serum choline decline after coronary artery bypass grafting surgery
Keywords: brain injury, cognitive decline, coronary artery surgery, free choline, neuron-specific enolase (NSE), S-100?
The aims of this study were to determine circulating choline status and its relationship to circulating levels of S-100? protein and neuron-specific enolase, biochemical markers of cerebral injury and cognitive decline, after coronary artery bypass grafting (CABG) surgery. Preoperatively, patients scheduled for off-pump or on-pump CABG surgery had serum concentrations of 12.0±0.2 and 11.7±0.4 ?mol/L free choline and 2640±65 and 2675±115 ?mol/L phospholipid-bound choline, respectively. Serum free and bound choline levels decreased by 22–37% or 34–47% and 16–36% or 31–38% at 48 h after off-pump or on-pump surgery, respectively. Serum S-100? and neuron-specific enolase increased from preoperative values of 0.083±0.009 and 6.3±0.2 ?g/L to 0.405±0.022 and 11.4±0.8 ?g/L, respectively, at 0 h postoperatively and remained elevated for 48 h after off-pump surgery. Serum free and bound choline concentrations were inversely correlated with the concentrations of S-100? (r=?0.798; p<0.001 and r=?0.734; p<0.001) and neuron-specific enolase (r=?0.840; p<0.001 and r=?0.728; p<0.001). In conclusion, CABG surgery induces a decline in serum free and phospholipid-bound choline concentrations. The decreased serum choline concentrations were inversely correlated with the elevated levels of circulating cerebral injury markers. Thus, a decline in circulating choline may be involved in postoperative cognitive decline.
Clinical Chemical Laboratory Medicine, Walter de Gruyter
Print ISSN: 1434-6621
Volume: 44, 04/2006
Pages: 471 - 478