Toshiaki Okawa, Shinya Honda, Minoru Sanpei, Tomohiko Ishida, Keiya Fujimori, Akira Sato
Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep
Aims: To measure plasma concentrations of endothelin (ET)-1, NO metabolites (nitrate/nitrite; NOx) and 6-keto PGF1? (PGF1?) in maternal and fetal sheep blood, and to evaluate the effects of big ET-1 on hemodynamic response, blood gases and NO and 6-keto PGF1? production in near term fetal sheep.
Methods: Hemodynamic parameters were measured during infusion of big ET-1 into the carotid vein in chronically catheterized fetal sheep on day 125 of gestation. Fetal arterial blood samples were obtained for ET-1, PGF1?) and nitrate/nitrite (NOx) measurements.
Results: ET-1, NOx and PGF1? plasma concentrations were all significantly higher in fetal compared with the maternal plasma. Big ET-1 significantly decreased fetal systolic and diastolic blood pressure and significantly increased fetal heart rate. Big ET-1 stimulated plasma PGF1?), but not NOx, concentration.
Conclusions: Circulatory regulating factors in the fetus were up-regulated. The effects of ET-1 on fetal hemodynamic respnse may be mediated via prostacyclin, but not via the NO pathway.
Journal of Perinatal Medicine, Walter de Gruyter
Print ISSN: 1619-3997
Volume: 32, 11/2004
Pages: 495 - 499
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