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Liming Peng, Jing Yang, Xiaojun Lu, Tokuhiro Okada, Tamiaki Kondo, Changgeng Ruan, Yun Wu, Xiaomin Xin
Effects of biological variations on platelet count in healthy subjects in China
The effects of biological variations on platelet counts were investigated in 694 healthy subjects aged 18 to 60 years living in three cities including Chengdu (Sichuan Province), Suzhou (Jiangsu Province) and Harbin (Heilongjang Province) in China. Platelet counts in healthy subjects were significantly lower in Chengdu (52202 109/L) and Suzhou (60259 109/L) than in Harbin (154348 109/L)(p <0.0001), but the mean platelet volume (MPV) determined concurrently was negatively correlated with platelet count, the MPV values were significantly higher in Chengdu (11.815.6 fl) and Suzhou (10.915.8 fl) than in Harbin (9.512.9 fl) (p < 0.0001). Platelet counts were significantly higher in summer (73289 109/L) than in winter (52202 109/L) (p <0.0001), but the MPV values were lower in summer (11.214.7 fl) than in winter (11.815.6 fl) (p <0.05) in Chengdu. Platelet associated immunoglobulin (PA-IgG) in Chengdu was revealed to be significantly higher in the low platelet count group (<150 109/L, 13.5 7.1 ng/107 PLT) than in the normal platelet count group (150 109/L, 8.3 2.7 ng/107 PLT)(p <0.0001). Similar results were observed in Suzhou for the reticulated platelet ratio, which was significantly higher in the low platelet count group (19.5 7.1%) than in the normal platelet count group (11.6 2.7%)(p <0.01). The bleeding time in Chengdu showed a significantly longer time in the low platelet count group (8.6 2.3 min) than in the normal platelet count group (6.0 1.2 min)(p <0.01). With regard to the effects of lipids on platelet counts, the HDL values were significantly higher in the normal platelet count group (1.60 0.76 mmol/L) than the low platelet count group (1.23 0.31 mmol/L) (p <0.01); but no significant differences in cholesterol and triglycerides values between the normal and low platelet count groups (p >0.05) were recorded. These findings suggest that the platelet counts could be greatly influenced in healthy subjects by biological variations such as geographical, seasonal, and lipid variations.
Thrombosis and Haemostasis, Schattauer
Print ISSN: 0340-6245
Volume: 91
Pages: 367 - 372