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Enrico Cappellin, Elio F. De Palo, Rosalba Gatti, Giuseppe Soldà, Wolfgang Woloszczuk, Paolo Spinella

Effect of prolonged physical exercise on urinary proANP_1-30 and proANP_31-67

Keywords: atrial natriuretic peptide, kidney, physical exercise, proteinuria

Dynamic exercise strongly affects atrial natriuretic peptides (ANP), in particular the mature bioactive ?ANP and the proANP fragments, namely proANP_1–98, proANP_1–30 and proANP_31–67. The proANPs influence kidney functions and their plasma levels increase after physical exercise. We measured urinary proANP_1–30 and proANP_31–67 levels before and at the end of physical exercise in 28 well-trained male cyclists. For the first time, the proANP_1–30 and proANP_31–67 urinary levels in athletes before and at the end of a prolonged agonistic bicycle race were measured. Urinary creatinine and total proteins were also measured. The urinary proANP_31–67, creatinine and total protein levels were significantly higher at the end of exercise than before. In contrast, proANP_1–30/protein and proANP_31–67/protein ratios decreased after exercise. Even proANP_1–30/creatinine and proANP_31–67/creatinine ratios were lower after exercise. A significant correlation between proANP_1–30 and proANP_31–67 urinary levels at the end of exercise was found. The proANP_31–67/creatinine ratio before and after exercise also showed a significant correlation. The variation of urinary proANP fragments confirmed their possible role in physical exercise. In particular, it could be interpreted as a response of the body or kidney to renal impairment occurring during exercise.

Clinical Chemical Laboratory Medicine, Walter de Gruyter

Print ISSN: 1434-6621
Volume: 42, 09/2004
Pages: 1058 - 1062

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